Inhibition of neutrophil respiratory burst and degranulation responses by CVT-E002, the main active ingredient in COLD-FX
نویسندگان
چکیده
Background Human peripheral blood neutrophils contribute to the first line of defence in the immune system and are critical for maintaining health and immunity against opportunistic infections. Neutrophils and their granule-derived mediators are frequently found elevated in patient samples in viral infections, asthma exacerbations, and other respiratory ailments. COLD-FX has been shown to reduce the symptoms and severity of respiratory tract viral infections. Our hypothesis is that COLD-FX modulates neutrophil activity. To determine the effects of COLD-FX on neutrophils, peripheral blood neutrophils (>97% purity) were isolated from healthy human volunteers.
منابع مشابه
Efficacy and Safety of CVT-E002, a Proprietary Extract of Panax quinquefolius in the Prevention of Respiratory Infections in Influenza-Vaccinated Community-Dwelling Adults: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial
CVT-E002 (a proprietary extract) was found to be effective in the prevention of upper respiratory infections (URIs) in healthy adults, and institutionalized and community-dwelling seniors. A multicenter, randomized, double-blind, placebo-controlled trial was carried out to determine effects of CVT-E002 in the prevention of URIs in influenza-vaccinated community-dwelling adults. 783 community-dw...
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CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium) showed immunomodulating activity. Cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) are important drug-metabolizing enzymes. Modulation of drugmetabolizing enzymes is a main cause of drug interactions. To assess the possible metabolism-based drug interaction of CVT-E002...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2011